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A Phosphomimetic Mutation at Ser-138 Renders Iron Regulatory Protein 1 Sensitive to Iron-Dependent Degradation

Iron regulatory protein 1 (IRP1) binds to mRNA iron-responsive elements (IREs) and thereby controls the expression of IRE-containing mRNAs. In iron-replete cells, assembly of a cubane [4Fe-4S] cluster inhibits IRE-binding activity and converts IRP1 to a cytosolic aconitase. Earlier experiments with...

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Bibliografiske detaljer
Main Authors: Fillebeen, Carine, Chahine, Danielle, Caltagirone, Annie, Segal, Phillip, Pantopoulos, Kostas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC193948/
https://ncbi.nlm.nih.gov/pubmed/12972614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.19.6973-6981.2003
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