Single-molecule FRET reveals sugar-induced conformational dynamics in LacY

The N- and C-terminal six-helix bundles of lactose permease (LacY) form a large internal cavity open on the cytoplasmic side and closed on the periplasmic side with a single sugar-binding site at the apex of the cavity near the middle of the molecule. During sugar/H(+) symport, an outward-facing cav...

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Detaylı Bibliyografya
Asıl Yazarlar: Majumdar, Devdoot S., Smirnova, Irina, Kasho, Vladimir, Nir, Eyal, Kong, Xiangxu, Weiss, Shimon, Kaback, H. Ronald
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2007
Konular:
Single-molecule Chemistry and Biology Special Feature
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937519/
https://ncbi.nlm.nih.gov/pubmed/17502603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700969104
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