Brain fatty acid synthase activates PPARα to maintain energy homeostasis

Central nervous system control of energy balance affects susceptibility to obesity and diabetes, but how fatty acids, malonyl-CoA, and other metabolites act at this site to alter metabolism is poorly understood. Pharmacological inhibition of fatty acid synthase (FAS), rate limiting for de novo lipog...

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Hauptverfasser: Chakravarthy, Manu V., Zhu, Yimin, López, Miguel, Yin, Li, Wozniak, David F., Coleman, Trey, Hu, Zhiyuan, Wolfgang, Michael, Vidal-Puig, Antonio, Lane, M. Daniel, Semenkovich, Clay F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1937501/
https://ncbi.nlm.nih.gov/pubmed/17694178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31183
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