Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver

PPARα is activated by drugs to treat human disorders of lipid metabolism. Its endogenous ligand is unknown. PPARα-dependent gene expression is impaired with inactivation of fatty acid synthase (FAS), suggesting that FAS is involved in generation of a PPARα ligand. Here we demonstrate the FAS-depende...

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Bibliografski detalji
Glavni autori: Chakravarthy, Manu V., Lodhi, Irfan J., Yin, Li, Malapaka, Raghu R. V., Xu, H. Eric, Turk, John, Semenkovich, Clay F.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725194/
https://ncbi.nlm.nih.gov/pubmed/19646743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.05.036
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