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Identification of a Physiologically Relevant Endogenous Ligand for PPARα in Liver
PPARα is activated by drugs to treat human disorders of lipid metabolism. Its endogenous ligand is unknown. PPARα-dependent gene expression is impaired with inactivation of fatty acid synthase (FAS), suggesting that FAS is involved in generation of a PPARα ligand. Here we demonstrate the FAS-depende...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2725194/ https://ncbi.nlm.nih.gov/pubmed/19646743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.05.036 |
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