De Novo Lipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation

Endothelial dysfunction leads to lethal vascular complications in diabetes and related metabolic disorders. Here, we demonstrate that de novo lipogenesis, an insulin-dependent process driven by the multifunctional enzyme fatty-acid synthase (FAS), maintains endothelial function by targeting endothel...

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Autors principals: Wei, Xiaochao, Schneider, Jochen G., Shenouda, Sherene M., Lee, Ada, Towler, Dwight A., Chakravarthy, Manu V., Vita, Joseph A., Semenkovich, Clay F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2011
Matèries:
Molecular Bases of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024788/
https://ncbi.nlm.nih.gov/pubmed/21098489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.193037
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