Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity

To detect and characterize autoreactive T cells in diabetes-prone NOD mice, we have developed a multimeric MHC reagent with high affinity for the BDC-2.5 T cell receptor, which is reactive against a pancreatic autoantigen. A distinct population of T cells is detected in NOD mice that recognizes the...

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Detalhes bibliográficos
Main Authors: Stratmann, Thomas, Martin-Orozco, Natalia, Mallet-Designe, Valérie, Poirot, Laurent, McGavern, Dorian, Losyev, Grigoriy, Dobbs, Cathleen M., Oldstone, Michael B.A., Yoshida, Kenji, Kikutani, Hitoshi, Mathis, Diane, Benoist, Christophe, Haskins, Kathryn, Teyton, Luc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC193666/
https://ncbi.nlm.nih.gov/pubmed/12975475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318337
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