Novel high-throughput electrochemiluminescent assay for identification of human tyrosyl-DNA phosphodiesterase (Tdp1) inhibitors and characterization of furamidine (NSC 305831) as an inhibitor of Tdp1

By enzymatically hydrolyzing the terminal phosphodiester bond at the 3′-ends of DNA breaks, tyrosyl-DNA phosphodiesterase (Tdp1) repairs topoisomerase-DNA covalent complexes and processes the DNA ends for DNA repair. To identify novel Tdp1 inhibitors, we developed a high-throughput assay that uses e...

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Bibliographic Details
Main Authors: Antony, Smitha, Marchand, Christophe, Stephen, Andrew G., Thibaut, Laurent, Agama, Keli K., Fisher, Robert J., Pommier, Yves
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1935015/
https://ncbi.nlm.nih.gov/pubmed/17576665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm463
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