Following an environmental carcinogen N(2)-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase

We have investigated how a benzo[a]pyrene-derived N(2)-dG adduct, 10S(+)-trans-anti-[BP]-N(2)-dG ([BP]G*), is processed in a well-characterized Pol I family model replicative DNA polymerase, Bacillus fragment (BF). Experimental results are presented that reveal relatively facile nucleotide incorpora...

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Bibliographic Details
Main Authors: Xu, Pingna, Oum, Lida, Beese, Lorena S., Geacintov, Nicholas E., Broyde, Suse
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1934992/
https://ncbi.nlm.nih.gov/pubmed/17576677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm416
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