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Following an environmental carcinogen N(2)-dG adduct through replication: elucidating blockage and bypass in a high-fidelity DNA polymerase
We have investigated how a benzo[a]pyrene-derived N(2)-dG adduct, 10S(+)-trans-anti-[BP]-N(2)-dG ([BP]G*), is processed in a well-characterized Pol I family model replicative DNA polymerase, Bacillus fragment (BF). Experimental results are presented that reveal relatively facile nucleotide incorpora...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2007
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1934992/ https://ncbi.nlm.nih.gov/pubmed/17576677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm416 |
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