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Visualizing Sequence-Governed Nucleotide Selectivities and Mutagenic Consequences through a Replicative Cycle: Processing of a Bulky Carcinogen N(2)-dG Lesion in a Y-family DNA olymerase

Understanding how DNA polymerases process lesions remains fundamental to determining the molecular origins of mutagenic translesion bypass. We have investigated how a benzo[a]pyrene-derived N(2)-dG adduct, 10S (+)-trans-anti-[BP]-N(2)-dG ([BP]G*), is processed in Dpo4, the well-characterized Y-famil...

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書目詳細資料
Main Authors: Xu, Pingna, Oum, Lida, Lee, Yuan-Cho, Geacintov, Nicholas E., Broyde, Suse
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929011/
https://ncbi.nlm.nih.gov/pubmed/19364137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802363f
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