Notch-induced T cell development requires phosphoinositide-dependent kinase 1

Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK). PDK1 is required for thymocyte differentiation and proliferation, and herein, we explore the molecular...

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Detalhes bibliográficos
Main Authors: Kelly, April P, Finlay, David K, Hinton, Heather J, Clarke, Rosie G, Fiorini, Emma, Radtke, Freddy, Cantrell, Doreen A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933393/
https://ncbi.nlm.nih.gov/pubmed/17599070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601761
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