Mutations in Human Immunodeficiency Virus Type 1 RNase H Primer Grip Enhance 3′-Azido-3′-Deoxythymidine Resistance

We recently observed that mutations in the human immunodeficiency type 1 (HIV-1) reverse transcriptase (RT) connection domain significantly increase 3′-azido-3′-deoxythymidine (AZT) resistance up to 536 times over wild-type (WT) RT in the presence of thymidine analog resistance mutations (TAMs). The...

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Bibliographic Details
Main Authors: Delviks-Frankenberry, Krista A., Nikolenko, Galina N., Barr, Rebekah, Pathak, Vinay K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933283/
https://ncbi.nlm.nih.gov/pubmed/17428874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02820-06
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