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Mutations in the RNase H Primer Grip Domain of Murine Leukemia Virus Reverse Transcriptase Decrease Efficiency and Accuracy of Plus-Strand DNA Transfer

The RNase H primer grip of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) contacts the DNA primer strand and positions the template strand near the RNase H active site, influencing RNase H cleavage efficiency and specificity. Sequence alignments show that 6 of the 11 residues...

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Autors principals: Mbisa, Jean L., Nikolenko, Galina N., Pathak, Vinay K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC538714/
https://ncbi.nlm.nih.gov/pubmed/15596835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.1.419-427.2005
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