Hot spots in prion protein for pathogenic conversion

Prion proteins are key molecules in transmissible spongiform encephalopathies (TSEs), but the precise mechanism of the conversion from the cellular form (PrP(C)) to the scrapie form (PrP(Sc)) is still unknown. Here we discovered a chemical chaperone to stabilize the PrP(C) conformation and identifie...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kuwata, Kazuo, Nishida, Noriyuki, Matsumoto, Tomoharu, Kamatari, Yuji O., Hosokawa-Muto, Junji, Kodama, Kota, Nakamura, Hironori K., Kimura, Kiminori, Kawasaki, Makoto, Takakura, Yuka, Shirabe, Susumu, Takata, Jiro, Kataoka, Yasufumi, Katamine, Shigeru
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2007
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924567/
https://ncbi.nlm.nih.gov/pubmed/17616582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702671104
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