Hot spots in prion protein for pathogenic conversion

Prion proteins are key molecules in transmissible spongiform encephalopathies (TSEs), but the precise mechanism of the conversion from the cellular form (PrP(C)) to the scrapie form (PrP(Sc)) is still unknown. Here we discovered a chemical chaperone to stabilize the PrP(C) conformation and identifie...

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Autori principali: Kuwata, Kazuo, Nishida, Noriyuki, Matsumoto, Tomoharu, Kamatari, Yuji O., Hosokawa-Muto, Junji, Kodama, Kota, Nakamura, Hironori K., Kimura, Kiminori, Kawasaki, Makoto, Takakura, Yuka, Shirabe, Susumu, Takata, Jiro, Kataoka, Yasufumi, Katamine, Shigeru
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924567/
https://ncbi.nlm.nih.gov/pubmed/17616582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702671104
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