Hot spots in prion protein for pathogenic conversion

Prion proteins are key molecules in transmissible spongiform encephalopathies (TSEs), but the precise mechanism of the conversion from the cellular form (PrP(C)) to the scrapie form (PrP(Sc)) is still unknown. Here we discovered a chemical chaperone to stabilize the PrP(C) conformation and identifie...

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Detalhes bibliográficos
Main Authors: Kuwata, Kazuo, Nishida, Noriyuki, Matsumoto, Tomoharu, Kamatari, Yuji O., Hosokawa-Muto, Junji, Kodama, Kota, Nakamura, Hironori K., Kimura, Kiminori, Kawasaki, Makoto, Takakura, Yuka, Shirabe, Susumu, Takata, Jiro, Kataoka, Yasufumi, Katamine, Shigeru
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924567/
https://ncbi.nlm.nih.gov/pubmed/17616582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702671104
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