Hot spots in prion protein for pathogenic conversion

Prion proteins are key molecules in transmissible spongiform encephalopathies (TSEs), but the precise mechanism of the conversion from the cellular form (PrP(C)) to the scrapie form (PrP(Sc)) is still unknown. Here we discovered a chemical chaperone to stabilize the PrP(C) conformation and identifie...

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Dades bibliogràfiques
Autors principals: Kuwata, Kazuo, Nishida, Noriyuki, Matsumoto, Tomoharu, Kamatari, Yuji O., Hosokawa-Muto, Junji, Kodama, Kota, Nakamura, Hironori K., Kimura, Kiminori, Kawasaki, Makoto, Takakura, Yuka, Shirabe, Susumu, Takata, Jiro, Kataoka, Yasufumi, Katamine, Shigeru
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924567/
https://ncbi.nlm.nih.gov/pubmed/17616582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0702671104
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