Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders

Loss of a whole chromosome 5 or a deletion of the long arm, del(5q), is a recurring abnormality in myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML). To identify a leukemia-related gene on chromosome 5, we previously delineated a 970-kb segment of 5q31 that is deleted in all patients...

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Autori principali: Joslin, John M., Fernald, Anthony A., Tennant, Thelma R., Davis, Elizabeth M., Kogan, Scott C., Anastasi, John, Crispino, John D., Le Beau, Michelle M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2007
Soggetti:
Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924479/
https://ncbi.nlm.nih.gov/pubmed/17420284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-01-068809
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