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Haploinsufficiency of Apc leads to ineffective hematopoiesis
Loss of a whole chromosome 5 or a deletion of the long arm of chromosome 5, −5/del(5q), is a recurring abnormality in myeloid neoplasms. The APC gene is located at chromosome band 5q23, and is deleted in more than 95% of patients with a −5/del(5q), raising the question of whether haploinsufficiency...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372947/ https://ncbi.nlm.nih.gov/pubmed/20065296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-251835 |
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