Haploinsufficiency of Apc leads to ineffective hematopoiesis

Loss of a whole chromosome 5 or a deletion of the long arm of chromosome 5, −5/del(5q), is a recurring abnormality in myeloid neoplasms. The APC gene is located at chromosome band 5q23, and is deleted in more than 95% of patients with a −5/del(5q), raising the question of whether haploinsufficiency...

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Bibliographic Details
Main Authors: Wang, Jianghong, Fernald, Anthony A., Anastasi, John, Le Beau, Michelle M., Qian, Zhijian
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2010
Subjects:
Hematopoiesis and Stem Cells
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372947/
https://ncbi.nlm.nih.gov/pubmed/20065296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-251835
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