Expression of gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver.
Activation of the cellular immune system and subsequent lysis of vector-transduced cells by adenovirus- or transgene-specific cytotoxic T lymphocytes have been shown to limit transgene expression in animal models. The adenovirus gp19K gene product associates with major histocompatibility complex cla...
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| Published in: | J Virol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology (ASM)
1997
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC192111/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9311844/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.10.7623-7628.1997 |
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