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Expression of gp19K increases the persistence of transgene expression from an adenovirus vector in the mouse lung and liver.

Activation of the cellular immune system and subsequent lysis of vector-transduced cells by adenovirus- or transgene-specific cytotoxic T lymphocytes have been shown to limit transgene expression in animal models. The adenovirus gp19K gene product associates with major histocompatibility complex cla...

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Bibliografiske detaljer
Main Authors: Bruder, J T, Jie, T, McVey, D L, Kovesdi, I
Format: Artigo
Sprog:Inglês
Udgivet: 1997
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC192111/
https://ncbi.nlm.nih.gov/pubmed/9311844
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