Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding

The interferon regulatory transcription factor (IRF-3) is activated by phosphorylation of Ser/Thr residues clustered in its C-terminal domain. Phosphorylation of these residues, which increases the negative charge of IRF-3, results in its dimerization and association with DNA, despite the increase i...

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Hauptverfasser: Dragan, Anatoly I., Hargreaves, Victoria V., Makeyeva, Elena N., Privalov, Peter L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2007
Schlagworte:
Molecular Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1920236/
https://ncbi.nlm.nih.gov/pubmed/17483521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm142
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