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Discovery of an oncogenic activity in p27(Kip1) that causes stem cell expansion and a multiple tumor phenotype
The cell cycle inhibitor p27(Kip1) also has cyclin–cyclin-dependent kinase (CDK)-independent functions. To investigate the significance of these functions in vivo, we generated a knock-in mouse in which four amino acid substitutions in the cdkn1b gene product prevent its interaction with cyclins and...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1920168/ https://ncbi.nlm.nih.gov/pubmed/17626791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1556607 |
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