Inhibition of human immunodeficiency virus replication by the herpes simplex virus virion host shutoff protein.

The herpes simplex virus (HSV) virion host shutoff gene (vhs) encodes a protein which nonspecifically accelerates the degradation of mRNA molecules, leading to inhibition of protein synthesis. This ability to inhibit a critical cellular function suggested that vhs could be used as a suicide gene in...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Hamouda, T, McPhee, R, Hsia, S C, Read, G S, Holland, T C, King, S R
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC191794/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9188626/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.71.7.5521-5527.1997
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