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Conformational Dynamics of the αM3 Transmembrane Helix during Acetylcholine Receptor Channel Gating
Muscle acetylcholine receptors are synaptic ion channels that “gate” between closed- and open-channel conformations. We used Φ-value analysis to probe the transition state of the diliganded gating reaction with regard to residues in the M3, membrane-spanning helix of the muscle acetylcholine recepto...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1913136/ https://ncbi.nlm.nih.gov/pubmed/17513382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.105171 |
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