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Coupling of S4 Helix Translocation and S6 Gating Analyzed by Molecular-Dynamics Simulations of Mutated Kv Channels
The recently determined crystal structure of a chimeric Kv1.2-Kv2.1 Kv channel at 2.4 Å resolution motivated this molecular-dynamics simulation study of the chimeric channel and its mutants embedded in a DPPC membrane. For the channel protein, we used two types of C-terminus: E+ and Eo. E+ contains,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Biophysical Society
2009
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2711363/ https://ncbi.nlm.nih.gov/pubmed/19580747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.02.074 |
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