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Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy.

Recombinant adenoviruses with E1 sequences deleted efficiently transfer genes into a wide variety of target cells. Antigen- and nonantigen-specific responses to the therapy lead to toxicity, loss of transgene expression, and difficulties with vector readministration. We have created new cell lines t...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Gao, G P, Yang, Y, Wilson, J M
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190991/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8971023/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.12.8934-8943.1996
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