Mutation in fiber of adenovirus serotype 5 gene therapy vector decreases liver tropism

Recombinant adenovirus (Ad) vectors are widely used for both in vitro and in vivo gene transfer. However, intravenous administration of Ad vectors results mainly in hepatocyte transduction and subsequent hepatotoxicity. Coxsackie-adenovirus receptor (CAR) and αvβ integrins, which are functional rece...

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Bibliographic Details
Published in:Int J Clin Exp Med
Main Authors: Wang, Zhen, Wang, Baoming, Lou, Junfang, Yan, Jingyi, Gao, Lei, Geng, Ranshen, Yu, Bin
Format: Artigo
Language:Inglês
Published: e-Century Publishing Corporation 2014
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307438/
https://ncbi.nlm.nih.gov/pubmed/25663991
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