Optimization of adenoviral vector–mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro

Expression of the immune-stimulatory molecule Fms-like tyrosine kinase 3 ligand (Flt3L) and the conditional cytotoxic enzyme herpes simplex virus type 1 thymidine kinase (HSV1-TK) provides long-term immune-mediated survival of large glioblastoma multiforme (GBM) models in rodents. A limitation for p...

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Main Authors: Candolfi, Marianela, Pluhar, G. Elizabeth, Kroeger, Kurt, Puntel, Mariana, Curtin, James, Barcia, Carlos, Muhammad, A.K.M. Ghulam, Xiong, Weidong, Liu, Chunyan, Mondkar, Sonali, Kuoy, William, Kang, Terry, McNeil, Elizabeth A., Freese, Andrew B., Ohlfest, John R., Moore, Peter, Palmer, Donna, Ng, Phillip, Young, John D., Lowenstein, Pedro R., Castro, Maria G.
Format: Artigo
Jezik:Inglês
Izdano: Duke University Press 2007
Teme:
Basic and Translational Investigations
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1907414/
https://ncbi.nlm.nih.gov/pubmed/17522335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1215/15228517-2007-012
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