The transmembrane form of TNF-α drives autoantibody production in the absence of CD154: studies using MRL/Mp-Fas(lpr) mice

It is generally accepted that the interaction between CD40 and its ligand (CD154) plays a decisive role in contact-dependent help for T and B cells. In CD154-deficient MRL/Mp-Fas(lpr) (MRL/lpr) mice, however, high titres of IgG2a-type autoantibodies against small nuclear ribonucleoproteins (snRNPs)...

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Dettagli Bibliografici
Autori principali: Fujii, T, Okada, M, Mimori, T, Craft, J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2002
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1906522/
https://ncbi.nlm.nih.gov/pubmed/12390309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.2002.01982.x
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