IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J Mice

MRL/MpJ-Fas(lpr/lpr)/J (MRL(lpr)) mice develop lupus-like disease manifestations in an IL-21–dependent manner. IL-21 is a pleio-tropic cytokine that can influence the activation, differentiation, and expansion of B and T cell effector subsets. Notably, auto-reactive CD4(+) T and B cells spontaneousl...

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Auteurs principaux: Rankin, Andrew L., Guay, Heath, Herber, Deborah, Bertino, Sarah A., Duzanski, Tatyana A., Carrier, Yijun, Keegan, Sean, Senices, Mayra, Stedman, Nancy, Ryan, Mark, Bloom, Laird, Medley, Quintus, Collins, Mary, Nickerson-Nutter, Cheryl, Craft, Joe, Young, Deborah, Dunussi-Joannopoulos, Kyri
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3618484/
https://ncbi.nlm.nih.gov/pubmed/22231702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003871
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