Deficient Leptin Signaling Ameliorates Systemic Lupus Erythematosus Lesions in MRL/Mp-Fas(lpr) Mice

Leptin is secreted by adipocytes, the placenta, and the stomach. It not only controls appetite through leptin receptors in the hypothalamus, it also regulates immunity. In the current study, we produced leptin-deficient MRL/Mp-Fas(lpr) mice to investigate the potential role of leptin in autoimmunity...

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Detalhes bibliográficos
Main Authors: Fujita, Yoshimasa, Fujii, Takao, Mimori, Tsuneyo, Sato, Tomomi, Nakamura, Takuji, Iwao, Haruka, Nakajima, Akio, Miki, Miyuki, Sakai, Tomoyuki, Kawanami, Takafumi, Tanaka, Masao, Masaki, Yasufumi, Fukushima, Toshihiro, Okazaki, Toshiro, Umehara, Hisanori
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2014
Assuntos:
Clinical and Human Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897175/
https://ncbi.nlm.nih.gov/pubmed/24391210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301685
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