Rarity of autoantibodies to a major autoantigen, thyroid peroxidase, that interact with denatured antigen or with epitopes outside the immunodominant region

The nature of the autoantibody repertoire to the dominant autoantigen in human autoimmune thyroid disease is controversial. There is evidence that autoantibodies to thyroid peroxidase (TPO) interact with overlapping conformational epitopes in an immunodominant region and binding to denatured (DN) pr...

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Detalles Bibliográficos
Main Authors: GUO, J, WANG, Y, JAUME, JC, RAPOPORT, B, MCLACHLAN, SM
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 1999
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1905467/
https://ncbi.nlm.nih.gov/pubmed/10403911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2249.1999.00934.x
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