Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication.

Certain amino acid substitutions in the reverse transcriptase (RT), including D67N, K70R, T215Y, and K219Q, cause high-level resistance of human immunodeficiency virus type 1 (HIV-1) to zidovudine (3'-azidothymidine; AZT) and appear to approximate the template strand of the enzyme-template-prim...

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Hauptverfasser: Caliendo, A M, Savara, A, An, D, DeVore, K, Kaplan, J C, D'Aquila, R T
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1996
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC190052/
https://ncbi.nlm.nih.gov/pubmed/8642636
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