Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication.

Certain amino acid substitutions in the reverse transcriptase (RT), including D67N, K70R, T215Y, and K219Q, cause high-level resistance of human immunodeficiency virus type 1 (HIV-1) to zidovudine (3'-azidothymidine; AZT) and appear to approximate the template strand of the enzyme-template-primer co...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Caliendo, A M, Savara, A, An, D, DeVore, K, Kaplan, J C, D'Aquila, R T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190052/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8642636/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.4.2146-2153.1996
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