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Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes.

Herpes simplex virus type 1 mutants with certain lesions in the ICP27 gene show a 5- to 10-fold reduction in viral DNA synthesis. To determine how ICP27 promotes amplification of viral DNA, we examined the synthesis, accumulation, and stability of the essential viral replication proteins and steady-...

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書目詳細資料
發表在:J Virol
Principais autores: Uprichard, S L, Knipe, D M
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 1996
主題:
在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190026/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8627723/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.3.1969-1980.1996
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