Herpes simplex ICP27 mutant viruses exhibit reduced expression of specific DNA replication genes.
Herpes simplex virus type 1 mutants with certain lesions in the ICP27 gene show a 5- to 10-fold reduction in viral DNA synthesis. To determine how ICP27 promotes amplification of viral DNA, we examined the synthesis, accumulation, and stability of the essential viral replication proteins and steady-...
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| Pubblicato in: | J Virol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Microbiology (ASM)
1996
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC190026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8627723/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.70.3.1969-1980.1996 |
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