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Biological Functions of DNA Methyltransferase 1 Require Its Methyltransferase Activity

DNA methyltransferase 1 (DNMT1) has been reported to interact with a wide variety of factors and to contain intrinsic transcriptional repressor activity. When a conservative point mutation was introduced at the key catalytic residue, mutant DNMT1 failed to rescue any of the phenotypes of Dnmt1-null...

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Detalhes bibliográficos
Main Authors: Damelin, Marc, Bestor, Timothy H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900033/
https://ncbi.nlm.nih.gov/pubmed/17371843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00036-07
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