Synthesis and Antiviral Evaluation of Alkoxyalkyl Phosphate Conjugates of Cidofovir and Adefovir

Esterification of cidofovir (CDV), an antiviral nucleoside phosphonate, with alkyl or alkoxyalkyl groups increases antiviral activity by enhancing cell uptake and conversion to CDV diphosphate. Hexadecyloxypropyl-CDV (HDP-CDV) has been shown to be 40 to 100 times more active than CDV in vitro in cel...

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Autors principals: Ruiz, Jacqueline C., Beadle, James R., Aldern, Kathy A., Keith, Kathy A., Hartline, Caroll B., Kern, Earl R., Hostetler, Karl Y.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899528/
https://ncbi.nlm.nih.gov/pubmed/17367874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2006.09.005
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