Comparison of the Antiviral Activities of Alkoxyalkyl and Alkyl Esters of Cidofovir against Human and Murine Cytomegalovirus Replication In Vitro

Alkoxyalkyl esters of cidofovir (CDV) have substantially greater antiviral activity and selectivity than unmodified CDV against herpesviruses and orthopoxviruses in vitro. Enhancement of antiviral activity was also noted when cyclic CDV was esterified with alkoxyalkanols. In vitro antiviral activity...

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Autores principales: Wan, William B., Beadle, James R., Hartline, Caroll, Kern, Earl R., Ciesla, Stephanie L., Valiaeva, Nadejda, Hostetler, Karl Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC547274/
https://ncbi.nlm.nih.gov/pubmed/15673748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.2.656-662.2005
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