Oral Treatment of Murine Cytomegalovirus Infections with Ether Lipid Esters of Cidofovir

To improve the oral bioavailability of cidofovir (CDV), a series of ether lipid ester prodrugs were synthesized and evaluated for activity against murine cytomegalovirus (MCMV) infection. Four of these analogs, hexadecyloxypropyl (HDP)-CDV, octadecyloxyethyl (ODE)-CDV, oleyloxyethyl (OLE)-CDV, and o...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: Kern, Earl R., Collins, Deborah J., Wan, W. Brad, Beadle, James R., Hostetler, Karl Y., Quenelle, Debra C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2004
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514741/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15328119/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.9.3516-3522.2004
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