Oral Treatment of Murine Cytomegalovirus Infections with Ether Lipid Esters of Cidofovir

To improve the oral bioavailability of cidofovir (CDV), a series of ether lipid ester prodrugs were synthesized and evaluated for activity against murine cytomegalovirus (MCMV) infection. Four of these analogs, hexadecyloxypropyl (HDP)-CDV, octadecyloxyethyl (ODE)-CDV, oleyloxyethyl (OLE)-CDV, and o...

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Main Authors: Kern, Earl R., Collins, Deborah J., Wan, W. Brad, Beadle, James R., Hostetler, Karl Y., Quenelle, Debra C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC514741/
https://ncbi.nlm.nih.gov/pubmed/15328119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.9.3516-3522.2004
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