Role of mutations G-480 and C-6203 in the attenuation phenotype of Sabin type 1 poliovirus.

Of the 55 point mutations which distinguish the type 1 poliovirus vaccine strain (Sabin 1) from its neurovirulent progenitor (P1/Mahoney), two have been strongly implicated by previous studies as determinants of the attenuation phenotype. A change of an A to a G at position 480, located within the 5...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: McGoldrick, A, Macadam, A J, Dunn, G, Rowe, A, Burlison, J, Minor, P D, Meredith, J, Evans, D J, Almond, J W
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1995
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC189699/
https://ncbi.nlm.nih.gov/pubmed/7494267
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