Role of mutations G-480 and C-6203 in the attenuation phenotype of Sabin type 1 poliovirus.

Of the 55 point mutations which distinguish the type 1 poliovirus vaccine strain (Sabin 1) from its neurovirulent progenitor (P1/Mahoney), two have been strongly implicated by previous studies as determinants of the attenuation phenotype. A change of an A to a G at position 480, located within the 5...

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發表在:	J Virol
Principais autores:	McGoldrick, A, Macadam, A J, Dunn, G, Rowe, A, Burlison, J, Minor, P D, Meredith, J, Evans, D J, Almond, J W
格式:	Artigo
語言:	Inglês
出版:	American Society for Microbiology (ASM) 1995
主題:	Research Article
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189699/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7494267/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.12.7601-7605.1995
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