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Estrogen receptor-α mediates an intraovarian negative feedback loop on thecal cell steroidogenesis via modulation of CYP17A1 (cytochrome P450, steroid 17α-hydroxylase/17,20 lyase) expression
Excess androgen synthesis by thecal cells is invariably detrimental to preovulatory follicles in the ovary and considered a fundamental characteristic of polycystic ovary syndrome in women. Investigators have long postulated that granulosa cell-derived estrogens modulate thecal cell steroidogenesis...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1896370/ https://ncbi.nlm.nih.gov/pubmed/17158782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.06-6681com |
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