A nonsense polymorphism in the protein Z-dependent protease inhibitor increases the risk for venous thrombosis

The protein Z-dependent protease inhibitor (ZPI) is a hemostatic serpin with anticoagulant activity. As for antithrombin, deficiency of ZPI could have relevant thrombotic consequences. We have studied 6 genetic modifications affecting the ZPI gene, identifying 5 haplotypes. Haplotype H5 is featured...

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Detalhes bibliográficos
Main Authors: Corral, Javier, González-Conejero, Rocio, Soria, Jose Manuel, González-Porras, Jose Ramón, Pérez-Ceballos, Elena, Lecumberri, Ramón, Roldán, Vanessa, Souto, Juan Carlos, Miñano, Antonia, Hernández-Espinosa, David, Alberca, Ignacio, Fontcuberta, Jordi, Vicente, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895831/
https://ncbi.nlm.nih.gov/pubmed/16527896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-08-3249
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