l-Asparaginase-Induced Antithrombin Type I Deficiency : Implications for Conformational Diseases

Serpinopathies, a group of diseases caused by mutations that disrupt the structurally sensitive serpins, have no known acquired cause. Interestingly, l-asparaginase treatment of acute lymphoblastic leukemia patients causes severe deficiency in the serpin antithrombin. We studied the consequences of...

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Detalhes bibliográficos
Main Authors: Hernández-Espinosa, David, Miñano, Antonia, Martínez, Constantino, Pérez-Ceballos, Elena, Heras, Inmaculada, Fuster, José L., Vicente, Vicente, Corral, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698772/
https://ncbi.nlm.nih.gov/pubmed/16816368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051238
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