The Infective Polymerization of Conformationally Unstable Antithrombin Mutants May Play a Role in the Clinical Severity of Antithrombin Deficiency

Mutations affecting mobile domains of antithrombin induce conformational instability resulting in protein polymerization that associates with a severe clinical phenotype, probably by an unknown gain of function. By homology with other conformational diseases, we speculated that these variants might...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Martínez-Martínez, Irene, Navarro-Fernández, José, Águila, Sonia, Miñano, Antonia, Bohdan, Nataliya, de la Morena-Barrio, María Eugenia, Ordóñez, Adriana, Martínez, Constantino, Vicente, Vicente, Corral, Javier
Formato: Artigo
Idioma:Inglês
Publicado em: ScholarOne 2012
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3409284/
https://ncbi.nlm.nih.gov/pubmed/22481271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2119/molmed.2012.00017
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados