Novel Associations of VKORC1 Variants with Higher Acenocoumarol Requirements

BACKGROUND: Algorithms combining both clinical and genetic data have been developed to improve oral anticoagulant therapy. Three polymorphisms in two genes, VKORC1 and CYP2C9, are the main coumarin dose determinants and no additional polymorphisms of any relevant pharmacogenetic importance have been...

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Bibliografske podrobnosti
Main Authors: Anton, Ana Isabel, Cerezo-Manchado, Juan J., Padilla, Jose, Perez-Andreu, Virginia, Corral, Javier, Vicente, Vicente, Roldan, Vanessa, Gonzalez-Conejero, Rocio
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656883/
https://ncbi.nlm.nih.gov/pubmed/23691226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064469
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