TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

Hepcidin is an antimicrobial peptide secreted by the liver during inflammation that plays a central role in mammalian iron homeostasis. Here we demonstrate the endogenous expression of hepcidin by macrophages and neutrophils in vitro and in vivo. These myeloid cell types produced hepcidin in respons...

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Библиографические подробности
Главные авторы: Peyssonnaux, Carole, Zinkernagel, Annelies S., Datta, Vivekanand, Lauth, Xavier, Johnson, Randall S., Nizet, Victor
Формат: Artigo
Язык:Inglês
Опубликовано: © 2006 by The American Society of Hematology 2006
Предметы:
Phagocytes
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895778/
https://ncbi.nlm.nih.gov/pubmed/16391018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2259
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