HIF-1α expression regulates the bactericidal capacity of phagocytes

Hypoxia is a characteristic feature of the tissue microenvironment during bacterial infection. Here we report on our use of conditional gene targeting to examine the contribution of hypoxia-inducible factor 1, α subunit (HIF-1α) to myeloid cell innate immune function. HIF-1α was induced by bacterial...

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Main Authors: Peyssonnaux, Carole, Datta, Vivekanand, Cramer, Thorsten, Doedens, Andrew, Theodorakis, Emmanuel A., Gallo, Richard L., Hurtado-Ziola, Nancy, Nizet, Victor, Johnson, Randall S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2005
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1159132/
https://ncbi.nlm.nih.gov/pubmed/16007254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI23865
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