TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

Hepcidin is an antimicrobial peptide secreted by the liver during inflammation that plays a central role in mammalian iron homeostasis. Here we demonstrate the endogenous expression of hepcidin by macrophages and neutrophils in vitro and in vivo. These myeloid cell types produced hepcidin in respons...

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Detalhes bibliográficos
Main Authors: Peyssonnaux, Carole, Zinkernagel, Annelies S., Datta, Vivekanand, Lauth, Xavier, Johnson, Randall S., Nizet, Victor
Formato: Artigo
Idioma:Inglês
Publicado em: © 2006 by The American Society of Hematology 2006
Assuntos:
Phagocytes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895778/
https://ncbi.nlm.nih.gov/pubmed/16391018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2259
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