TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

Hepcidin is an antimicrobial peptide secreted by the liver during inflammation that plays a central role in mammalian iron homeostasis. Here we demonstrate the endogenous expression of hepcidin by macrophages and neutrophils in vitro and in vivo. These myeloid cell types produced hepcidin in respons...

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Bibliografski detalji
Glavni autori: Peyssonnaux, Carole, Zinkernagel, Annelies S., Datta, Vivekanand, Lauth, Xavier, Johnson, Randall S., Nizet, Victor
Format: Artigo
Jezik:Inglês
Izdano: © 2006 by The American Society of Hematology 2006
Teme:
Phagocytes
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895778/
https://ncbi.nlm.nih.gov/pubmed/16391018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2259
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