TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

Hepcidin is an antimicrobial peptide secreted by the liver during inflammation that plays a central role in mammalian iron homeostasis. Here we demonstrate the endogenous expression of hepcidin by macrophages and neutrophils in vitro and in vivo. These myeloid cell types produced hepcidin in respons...

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Autors principals: Peyssonnaux, Carole, Zinkernagel, Annelies S., Datta, Vivekanand, Lauth, Xavier, Johnson, Randall S., Nizet, Victor
Format: Artigo
Idioma:Inglês
Publicat: © 2006 by The American Society of Hematology 2006
Matèries:
Phagocytes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895778/
https://ncbi.nlm.nih.gov/pubmed/16391018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2259
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