Expansion of HIV-specific CD4(+) and CD8(+) T cells by dendritic cells transfected with mRNA encoding cytoplasm- or lysosome-targeted Nef

Transfection with synthetic mRNA is a safe and efficient method of delivering antigens to dendritic cells for immunotherapy. Targeting antigens to the lysosome can sometimes enhance the CD4(+) T-cell response. We transfected antigen-presenting cells (APCs) with mRNA encoding Gag-p24 and cytoplasmic,...

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Autori principali: Kavanagh, Daniel G., Kaufmann, Daniel E., Sunderji, Sherzana, Frahm, Nicole, Le Gall, Sylvie, Boczkowski, David, Rosenberg, Eric S., Stone, David R., Johnston, Mary N., Wagner, Bradford S., Zaman, Mohammad T., Brander, Christian, Gilboa, Eli, Walker, Bruce D., Bhardwaj, Nina
Natura: Artigo
Lingua:Inglês
Pubblicazione: © 2006 by The American Society of Hematology 2006
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895708/
https://ncbi.nlm.nih.gov/pubmed/16249391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1513
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